6,7FDA warns against the use of injectable glutathione as a skin whitener because whitening is not an approved use,9 efficacy is not well-established, and there have been reported side effects(acute renal failure, severe drug reactions such as generalized morbilliform eruption with angioedema and urticaria, vasculitis, anaphylactic shock and many documented side effects based on studies on IV glutathione used as skin whitening).6,7,8, 12
DFO has been the most extensively studied in IN delivery experiments
Furthermore, PKM2 activation contributes to the intracellular accumulation of succinate, a signaling metabolite that stabilizes HIF-1 and promotes interleukin-1 beta (IL-1) production during inflammatory responses (Tannahill et al., 2013)
The blood circulation of HA-RM-Cel-BR was prolonged by RM encapsulation, and its targeting to RA was enhanced by HA modification
Toxicol Sci